Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis.

@article{Vincent1998DeterminantSA,
  title={Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis.},
  author={Angela C Vincent and Nick Willcox and Mary Martha Meyer Hill and J. C. Curnow and Calman A MacLennan and David Beeson},
  journal={Immunological reviews},
  year={1998},
  volume={164},
  pages={157-68}
}
In myasthenia gravis (MG), antibodies to the muscle acetylcholine receptor (AChR) cause muscle weakness. Experimental autoimmune myasthenia gravis (EAMG) can be induced by immunisation against purified AChR; the main immunogenic region (MIR) is a conformation-dependent site that includes alpha 67-76. EAMG can also occur after immunisation against extracellular AChR sequences, but this probably involves intramolecular determinant spreading. In MG patients, thymic hyperplasia and germinal centres… CONTINUE READING

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