Determinant spreading: lessons from animal models and human disease.

  title={Determinant spreading: lessons from animal models and human disease.},
  author={James McCluskey and A Darise Farris and Catherine L. Keech and Anthony W. Purcell and Maureen Rischmueller and Gin Kinoshita and Pakathip Reynolds and Thomas P. Gordon},
  journal={Immunological reviews},
Spreading of the immune response is a common theme in organ-specific and systemic autoimmune diseases. We evaluated whether some of the mixed antinuclear antibody patterns characteristic of systemic autoimmunity might be the result of determinant spreading from a single initiating event. Immunisation of healthy mice with individual protein components of the La/Ro ribonucleoprotein (RNP) targeted in systemic lupus erythematosus and primary Sjögren's syndrome induced autoantibodies recognising… CONTINUE READING


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