Determinant Role of Membrane Helices in KATP Channel Gating

@article{Wang2005DeterminantRO,
  title={Determinant Role of Membrane Helices in KATP Channel Gating},
  author={Runping Wang and Aar{\'o}n Rojas and Jianping Wu and Hailan Piao and Carmen Y Adams and Haoxing Xu and Yun Zhong Shi and Yinfeng Wang and Cai-ling Jiang},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={204},
  pages={1-10}
}
The ATP-sensitive K+ (KATP) channels couple chemical signals to cellular activity, in which the control of channel opening and closure (i.e., channel gating) is crucial. Transmembrane helices play an important role in channel gating. Here we report that the gating of Kir6.2, the core subunit of pancreatic and cardiac KATP channels, can be switched by manipulating the interaction between two residues located in transmembrane domains (TM) 1 and 2 of the channel protein. The Kir6.2 channel is… CONTINUE READING

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