Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits.

@article{Pongo2001DeteriorationOT,
  title={Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits.},
  author={E Pongo and Zsolt Balla and Kanigula Mubagwa and Willem J Flameng and Istv{\'a}n {\'E}des and Zolt{\'a}n Szilv{\'a}ssy and P{\'e}ter Ferdinandy},
  journal={European journal of pharmacology},
  year={2001},
  volume={418 3},
  pages={217-23}
}
We studied the effect of experimental hypercholesterolaemia/atherosclerosis on changes in coronary flow and cardiac function, induced by protein kinase C and ATP-sensitive K(+) (K(ATP)) channel modulators in isolated Langendorff-perfused rabbit hearts. Both phorbol 12-myristate-13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB, 0.1 microM each), activators… CONTINUE READING