Detergent structure and associated lipid as determinants in the stabilization of solubilized Ca2+-ATPase from sarcoplasmic reticulum.

@article{Lund1989DetergentSA,
  title={Detergent structure and associated lipid as determinants in the stabilization of solubilized Ca2+-ATPase from sarcoplasmic reticulum.},
  author={Swedenwinther Lund and St{\'e}phane Orlowski and B{\'e}atrice de Foresta and Philippe Champeil and Marc le Maire and Jesper Vuust M\oller},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 9},
  pages={4907-15}
}
The properties of detergents required to substitute the lipid environment of sarcoplasmic reticulum Ca2+-ATPase with retention of good functional properties were determined by the use of a large number of diverse detergents and delipidated enzyme. Detergents having an intermediate chain length (approximately equal to C12) and a polyoxyethylene glycol or carbohydrate polar group were optimal for Ca2+-ATPase function and stabilization, while detergents with short alkyl chain (C8) or bulky head… CONTINUE READING

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