Detergent release prolongs the lifetime of native-like membrane protein conformations in the gas-phase.

Abstract

Recent studies have suggested that detergents can protect the structure of membrane proteins during their transition from solution to the gas-phase. Here we provide mechanistic insights into this process by interrogating the structures of membrane protein-detergent assemblies in the gas-phase using ion mobility mass spectrometry. We show a clear correlation… (More)
DOI: 10.1021/ja401736v

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