Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction

  title={Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction},
  author={Srikanth Vasudevan and Jiying Huang and Barry R Botterman and Hani S. Matloub and E. W. Keefer and Jonathan Cheng},
  booktitle={Plastic and reconstructive surgery. Global open},
BACKGROUND Long-gap peripheral nerve defects arising from tumor, trauma, or birth-related injuries requiring nerve reconstruction are currently treated using nerve autografts and nerve allografts. Autografts are associated with limited supply and donor-site morbidity. Allografts require administration of transient immunosuppressants, which has substantial associated risks. To overcome these limitations, we investigated the use of detergent-free decellularized nerve grafts to reconstruct long… CONTINUE READING
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