Detergent decellularization of heart valves for tissue engineering: toxicological effects of residual detergents on human endothelial cells.

@article{Cebotari2010DetergentDO,
  title={Detergent decellularization of heart valves for tissue engineering: toxicological effects of residual detergents on human endothelial cells.},
  author={Serghei Cebotari and Igor Tudorache and Thomas J{\"a}kel and Andres Hilfiker and Suzanne E. Dorfman and Waldemar Ternes and Axel Haverich and Artur Lichtenberg},
  journal={Artificial organs},
  year={2010},
  volume={34 3},
  pages={206-10}
}
Detergents are powerful agents for tissue decellularization. Despite this, the high toxicity of detergent residua can be a major limitation. This study evaluated the efficacy of detergent removal from decellularized pulmonary valves (PVs) and the consequences of repopulation with human endothelial cells (HECs). Porcine PVs were treated with 1% sodium deoxycholate (SDC), group A; 1% sodium dodecyl sulfate (SDS), group B; and a mixture of 0.5% SDC/0.5% SDS, group C (n = 5 each). After each of 10… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…