Detemir as a once-daily basal insulin in type 2 diabetes

  title={Detemir as a once-daily basal insulin in type 2 diabetes},
  author={Scott E Nelson},
  booktitle={Clinical pharmacology : advances and applications},
BACKGROUND Insulin detemir, a long-acting basal insulin analog, is labeled for once-daily or twice-daily dosing in patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. Protocols for some earlier clinical studies of detemir evaluated twice-daily dosing, which may have generated the misperception that detemir should be prescribed twice daily for most patients. This review examines pharmacokinetic and pharmacodynamic (PK/PD), observational, and controlled studies that have evaluated… CONTINUE READING
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