Detection of zeptomole quantities of nonfluorescent molecules in a 10(1) nm nanochannel by thermal lens microscopy.

@article{Le2014DetectionOZ,
  title={Detection of zeptomole quantities of nonfluorescent molecules in a 10(1) nm nanochannel by thermal lens microscopy.},
  author={Thu H H Le and Kazuma Mawatari and Hisashi Shimizu and Takehiko Kitamori},
  journal={The Analyst},
  year={2014},
  volume={139 11},
  pages={2721-5}
}
Nanofluidics in 10(1) nm space, whose scale is comparable to the electric double layer (EDL) and the size of biomolecules, promises novel functional analytical devices. However, the detection, which is indispensable to the integrated chemical system, is still challenging in such an ultra-small space. Previously, we reported a differential interference contrast thermal lens microscope (DIC-TLM) based on the photothermal interferometry principle and succeeded in detection of nonfluorescent… CONTINUE READING
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