Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

@inproceedings{Verbanck2018DetectionOW,
  title={Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases},
  author={Marie Verbanck and Chia-Yen Chen and Benjamin M. Neale and Ron Do},
  booktitle={Nature Genetics},
  year={2018}
}
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the ‘no horizontal pleiotropy’ assumption can cause severe bias in MR. We developed the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test to identify horizontal pleiotropic outliers in multi-instrument summary-level MR testing. We showed using simulations that the MR-PRESSO test is best suited when horizontal… CONTINUE READING
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