Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets.

  title={Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets.},
  author={Misako Suzuki and Mitsuru Murata and Yumiko Matsubara and Toshihiro Uchida and Hiroaki Ishihara and Toshiro Shibano and Shin-ichiro Ashida and Kenji Soejima and Yasunori Okada and Yasuo Ikeda},
  journal={Biochemical and biophysical research communications},
  volume={313 1},
The hemostatic activity of von Willebrand factor (vWF) is strongly dependent on its multimeric structure, with the highest activity in 'unusually large' multimers secreted from endothelial cells. The multimeric structure is regulated by a plasma protease, vWF-cleaving protease (vWF-CP, or ADAMTS-13). ADAMTS-13 mRNA is variably expressed in liver and other tissues. Because 15-25% of circulating vWF is stored in platelets, the presence and function of ADAMTS-13 in platelets are important issues… CONTINUE READING

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