Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: A feasibility study

@inproceedings{Boutet2014DetectionOV,
  title={Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: A feasibility study},
  author={Claire Boutet and Marie Chupin and St{\'e}phane Leh{\'e}ricy and Linda Marrakchi-Kacem and St{\'e}phane Epelbaum and C Poupon and Christopher H. Wiggins and Alexandre Vignaud and Dominique Hasboun and B{\'e}n{\'e}dicte Defontaines and Olivier Hanon and Bruno Dubois and Marie Sarazin and Lucie Hertz-Pannier and Olivier Colliot},
  booktitle={NeuroImage: Clinical},
  year={2014}
}
In Alzheimer's disease (AD), the hippocampus is an early site of tau pathology and neurodegeneration. Histological studies have shown that lesions are not uniformly distributed within the hippocampus. Moreover, alterations of different hippocampal layers may reflect distinct pathological processes. 7 T MRI dramatically improves the visualization of hippocampal subregions and layers. In this study, we aimed to assess whether 7 T MRI can detect volumetric changes in hippocampal layers in vivo in… CONTINUE READING
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