Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens.

@article{Shimamura2000DetectionOV,
  title={Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens.},
  author={Tadashi Shimamura and Satoru Saito and Kazutoyo Morita and Takatoshi Kitamura and Manabu Morimoto and Takayoshi Kiba and Kazushi Numata and Katsuaki Tanaka and Hisahiko Sekihara},
  journal={Journal of gastroenterology and hepatology},
  year={2000},
  volume={15 6},
  pages={640-6}
}
BACKGROUND Vascular endothelial growth factor (VEGF) exerts its actions on the microvasculature, by interacting with specific endothelial cell receptors, and thus, contributes to angiogenesis and growth in many tumours. METHODS Using nested reverse-transcription-polymerase chain reaction, we examined the biopsy specimens of 14 patients with human hepatocellular carcinoma (HCC) and cirrhosis, for the expression of hepatic VEGF, and the VEGF receptors KDR and fit-1. To avoid the influence of… CONTINUE READING

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