Detection of urinary TGF-alpha by HPLC and western blot in patients with melanoma.


Transforming growth factor-alpha (TGF-alpha) secretion in the urine may reflect autonomous production by neoplasms. Previous measurements of TGF-alpha in the urine were limited by the large volumes of urine required for detection. Sensitive assays are required to detect TGF-alpha in small urine samples from individual patients with melanoma. An assay which… (More)