Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.

  title={Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.},
  author={Helen M. Yull and Diane L Ritchie and Jan P. M. Langeveld and Fred G. van Zijderveld and Moira E. Bruce and James W Ironside and Mark W Head},
  journal={The American journal of pathology},
  volume={168 1},
Molecular typing of the abnormal form of the prion protein (PrP(Sc)) has come to be regarded as a powerful tool in the investigation of the prion diseases. All evidence thus far presented indicates a single PrP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably resulting from infection with a single strain of the agent (bovine spongiform encephalopathy). Here we show for the first time that the PrP(Sc) that accumulates in the brain in variant Creutzfeldt-Jakob… CONTINUE READING
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