Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism.

@article{Oh2009DetectionOT,
  title={Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism.},
  author={Seh-hoon Oh and Rafal P. Witek and Si Hyun Bae and Houda A Darwiche and Youngmi Jung and Liya Pi and Alicia R Brown and Bryon E. Petersen},
  journal={Stem cells and development},
  year={2009},
  volume={18 1},
  pages={37-46}
}
Adult bone marrow (BM)-derived insulin-producing cells (IPCs) are capable of regulating blood glucose levels in chemically induced hyperglycemic mice. Using cell transplantation therapy, fully functional BM-derived IPCs help to mediate treatment of diabetes mellitus. Here, we demonstrate the detection of the pentose phosphate pathway enzyme, transketolase (TK), in BM-derived IPCs cultured under high-glucose conditions. Benfotiamine, a known activator of TK, was not shown to affect the… CONTINUE READING