Detection of transforming growth factor-alpha in the serum of gastric carcinoma patients.

@article{Choi1999DetectionOT,
  title={Detection of transforming growth factor-alpha in the serum of gastric carcinoma patients.},
  author={Jin-Hyuk Choi and Hee - Cheol Ezra Kim and Ho-yeong Lim and Dong Ki Nam and Hee Sun Kim and S. Y. Yi and K. S. Shim and Woon Sup Han},
  journal={Oncology},
  year={1999},
  volume={57 3},
  pages={236-41}
}
Transforming growth factor-alpha (TGF-alpha) is a ligand for epidermal growth factor receptor (EGFR) and it is overexpressed in various malignancies including lung, esophageal, colorectal, ovarian and gastric carcinomas. In patients with gastric carcinoma, its overexpression may be associated with advanced stage or poor prognosis. We have recently demonstrated that the mean serum level for EGFR in gastric carcinoma patients was significantly elevated compared with that of healthy controls… CONTINUE READING