Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells.

Abstract

Overexpressing StAR (a mitochondrial cholesterol transporter) increases (>5-fold) the rate of 27-hydroxylation of cholesterol and the rates of bile acid synthesis in primary rat hepatocytes; suggesting that the transport of cholesterol into mitochondria is rate-limiting for bile acid biosynthesis via the CYP27A1 initiated 'acidic' pathway. Our objective was… (More)

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Cite this paper

@article{Hall2005DetectionOT, title={Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells.}, author={E. A. W. Hall and Sichong Ren and Philip B. Hylemon and Daniel Rodr{\'i}guez-Agudo and Kaye Redford and Dalila Marques and D Kang and Gregorio Gil and William M. Pandak}, journal={Biochimica et biophysica acta}, year={2005}, volume={1733 2-3}, pages={111-9} }