Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.

@article{Markowitz1999DetectionOT,
  title={Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.},
  author={John Seth Markowitz and Barry K. Logan and Francis X Diamond and Kennerly S. Patrick},
  journal={Journal of clinical psychopharmacology},
  year={1999},
  volume={19 4},
  pages={362-6}
}
Methylphenidate is the most commonly prescribed psychostimulant in clinical use today. Known methylphenidate metabolites include ritalinic acid, corresponding lactams, and p-hydroxymethylphenidate. Recent in vitro work using rat liver preparations has indicated that the methylphenidate ethyl ester, ethylphenidate, is formed upon incubation with ethanol. This report describes the first detection of ethylphenidate in human blood and liver samples obtained from two suicide victims who had… CONTINUE READING

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