Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

Abstract

Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and study type (in vitro or in vivo). To acquire more insight into this, we assessed the transcriptomic effects of… (More)
DOI: 10.1007/s00204-014-1365-9

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