Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high-performance liquid chromatography/electrospray ionization mass spectrometry analysis.

Abstract

RATIONALE Cephalosporins (e.g. cephalexin, cefradine) are a major group of widely used β-lactam antibiotics. Hydrolysis of the β-lactam ring is an important reaction (often undesired) which leads to deactivation of β-lactams. To the best of our knowledge there is no electrospray ionization mass spectrometry (ESI-MS) data reported concerning the products of… (More)
DOI: 10.1002/rcm.8073

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