Detection of the Philadelphia chromosome in interphase nuclei.


Double fluorescence in situ hybridization was used to detect Philadelphia (Ph) chromosomes in interphase nuclei and metaphases of patients with chronic myeloid leukemia. Application of cosmid probes for 3' ABL and 5' BCR sequences gave better results than libraries for chromosomes 9 and 22. The present approach may provide an alternative method for… (More)


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@article{Arnoldus1990DetectionOT, title={Detection of the Philadelphia chromosome in interphase nuclei.}, author={E. P. J. Arnoldus and Joop C. A. G. Wiegant and I A Noordermeer and Judith Wessels and Geoffrey C. Beverstock and Gerard C. Grosveld and Marinus van der Ploeg and Achim Raap}, journal={Cytogenetics and cell genetics}, year={1990}, volume={54 3-4}, pages={108-11} }