Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology

  title={Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology},
  author={Makoto Yoshiba and Hiroaki Okamoto and Shunji Mishiro},
  journal={The Lancet},
High prevalence of GB virus C infection in a group of Italian patients with hepatitis of unknown etiology.
The alignment of the predicted translation products identified two recurrent amino acid substitutions in 6 patients, suggesting the possible existence of at least 2 different GBV-C subtypes, contributing to a significant number of the cases of hepatitis of unknown etiology in Italy.
Antibodies to the E2 protein of GB virus C/hepatitis G virus: low prevalence in Asian countries.
Occurrence & nucleotide sequence analysis of hepatitis G virus in patients with acute viral hepatitis & fulminant hepatitis.
HGV infection was not found to be clinically significant as well as nonpathogenic in the patients of FH and AVH and appeared to be an innocent bystander in the course of the disease.
The clinical significance of the detection of hepatitis GBV‐C RNA in the serum of patients with fulminant, presumed viral, hepatitis
This study does not support the hypothesis that the detection of hepatitis G virus (HGV)/GBV‐C RNA in the serum of patients with fulminant hepatitis indicates a causal association, but it does demonstrate that a careful transfusion history and screening of blood products is vital before the importance of GBV‐ C in the aetiology of fulminants hepatitis can be established.
Detection of hepatitis G virus RNA in patients with acute non‐A–E hepatitis
HGV appears to play a role in the pathogenesis of acute viral hepatitis; however, the etiology of a significant number of hepatitis cases remains unclear, suggesting the existence of an additional agent(s).
High prevalence of hepatitis G virus infection compared with hepatitis C virus infection in patients undergoing chronic hemodialysis.
  • L. Sheng, A. Widyastuti, S. Yap
  • Medicine, Biology
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1998
There is a high prevalence of HGV infection in patients undergoing hemodialysis in this patient population compared with HCV, and it is confirmed that HGV infections alone is not associated with elevated serum transaminases, and the appearance of anti-HGV-E2 is usually accompanied with clearance of serum HGV-RNA.
Prevalence of infection with hepatitis G virus among various groups in Thailand.
Results confirm a parenteral route of transmission for HGV and emphasise the need for further research to determine the clinical significance of this virus.


Isolation of novel virus-like sequences associated with human hepatitis
The limited nucleotide sequence identity betweenGBV-A, GBV-B and HCV sequences suggests that a novel virus, tentatively named GB virus C, may be responsible for some cases of non-A/B/B, non-C/C/D/E hepatitis.
Viral Hepatitis in Japan
The continuing increase in the total number of HCC cases in Japan can be attributed to an increase of HCV caused by HCC, and 70% of patients have serologic markers for HCV infection.
Contribution of hepatitis C virus to non‐A, non‐B fulminant hepatitis in Japan
Compared with type B fulminant hepatitis, type C and most cases of non‐A, non‐B fulminants hepatitis in Japan are, thus, characterized by slower and less severe but more persistent hepatocyte destruction.
Identification of two flavivirus-like genomes in the GB hepatitis agent.
Limited sequence identity with various isolates of hepatitis C virus and the relative positions of putative RNA helicases and RNA-dependent RNA polymerases in the predicted protein products of these molecules suggested that the GB agent contains two unique flavivirus-like genomes.
Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a
Results indicate superinfection with HCV of different genotypes in chimpanzees, newly introduced HCV replacing or being expelled by the predecessor HCV with each infection inducing an episode of liver injury.
Toga virus‐like particles in acute liver failure attributed to sporadic non‐A, non‐B hepatitis and recurrence after liver transplantation
Toga virus‐like particles (typically 60‐70 nm: enveloped with small surface spikes) were detected in the native hepatectomy specimens in 7 of 18 patients grafted for acute liver failure attributed to
Viral Hepatitis and Liver Disease
Japan and Italy submitted many more HCV-related abstracts than those about other hepatitis viruses, while the reverse was true for Russia, China, and India, where the authors know enteric ally transmitted hepatitis is prevalent and HBV is more important than HCV as the cause of chronic liver disease.
The data reported in these studies indicate that marmosets may be susceptible to human hepatitis, and if these observations are confirmed, these animals may provide good experimental models for this disease.