Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology

@article{Yoshiba1995DetectionOT,
  title={Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology},
  author={Makoto Yoshiba and Hiroaki Okamoto and Shunji Mishiro},
  journal={The Lancet},
  year={1995},
  volume={346},
  pages={1131-1132}
}
High prevalence of GB virus C infection in a group of Italian patients with hepatitis of unknown etiology.
TLDR
The alignment of the predicted translation products identified two recurrent amino acid substitutions in 6 patients, suggesting the possible existence of at least 2 different GBV-C subtypes, contributing to a significant number of the cases of hepatitis of unknown etiology in Italy.
Antibodies to the E2 protein of GB virus C/hepatitis G virus: low prevalence in Asian countries.
Occurrence & nucleotide sequence analysis of hepatitis G virus in patients with acute viral hepatitis & fulminant hepatitis.
TLDR
HGV infection was not found to be clinically significant as well as nonpathogenic in the patients of FH and AVH and appeared to be an innocent bystander in the course of the disease.
The clinical significance of the detection of hepatitis GBV‐C RNA in the serum of patients with fulminant, presumed viral, hepatitis
TLDR
This study does not support the hypothesis that the detection of hepatitis G virus (HGV)/GBV‐C RNA in the serum of patients with fulminant hepatitis indicates a causal association, but it does demonstrate that a careful transfusion history and screening of blood products is vital before the importance of GBV‐ C in the aetiology of fulminants hepatitis can be established.
Detection of hepatitis G virus RNA in patients with acute non‐A–E hepatitis
TLDR
HGV appears to play a role in the pathogenesis of acute viral hepatitis; however, the etiology of a significant number of hepatitis cases remains unclear, suggesting the existence of an additional agent(s).
High prevalence of hepatitis G virus infection compared with hepatitis C virus infection in patients undergoing chronic hemodialysis.
  • L. Sheng, A. Widyastuti, S. Yap
  • Medicine, Biology
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1998
TLDR
There is a high prevalence of HGV infection in patients undergoing hemodialysis in this patient population compared with HCV, and it is confirmed that HGV infections alone is not associated with elevated serum transaminases, and the appearance of anti-HGV-E2 is usually accompanied with clearance of serum HGV-RNA.
Prevalence of infection with hepatitis G virus among various groups in Thailand.
TLDR
Results confirm a parenteral route of transmission for HGV and emphasise the need for further research to determine the clinical significance of this virus.
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