Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons.

@article{Hummel2005DetectionOT,
  title={Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons.},
  author={Susanne Hummel and Dominic Schmidt and Barbara Kremeyer and Bernd Herrmann and Malte Oppermann},
  journal={Genes and immunity},
  year={2005},
  volume={6 4},
  pages={
          371-4
        }
}
A mutant allele of the chemokine receptor CCR5 gene (CCR5-Delta32), which confers resistance to HIV-1 infection, is believed to have originated from a single mutation event in historic times, and rapidly expanded in Caucasian populations, owing to an unknown selective advantage. Among other candidates, the plague bacillus Yersinia pestis was implicated as a potential source of strong selective pressure on European populations during medieval times. Here, we report amplifications of the CCR5… CONTINUE READING

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