• Biology, Medicine
  • Published in
    The American journal of…
    1993

Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.

@article{Downing1993DetectionOT,
  title={Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.},
  author={James R. Downing and David R. Head and David M Parham and Edwin C. Douglass and M G Hulshof and Michael P. Link and T A Motroni and Holcombe E. Grier and A M Curcio-Brint and David N. Shapiro},
  journal={The American journal of pathology},
  year={1993},
  volume={143 5},
  pages={
          1294-300
        }
}
Ewing's sarcoma and the related primitive neuroectodermal tumor (PNET) share a unique and specific t(11;22)(q24;q12) chromosomal translocation. The breakpoints have recently been cloned and shown to involve the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11. Translocation results in the fusion of these genes on the der(22) chromosome, resulting in the production of a novel chimeric EWS/FLI-1 message. Using oligonucleotide primers derived from EWS and FLI-1 complementary DNAs, we… CONTINUE READING

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Detection of t(11;22)(q24;q12) Translocation and EWS-FLI-1 Fusion Transcript in a Case of Solid Pseudopapillary Tumor of the Pancreas

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