Detection of sweet and umami taste in the absence of taste receptor T1r3.

@article{Damak2003DetectionOS,
  title={Detection of sweet and umami taste in the absence of taste receptor T1r3.},
  author={Sami Damak and Minqing Rong and Keiko Yasumatsu and Zaza Kokrashvili and Vijaya Varadarajan and Shiying Zou and Peihua Jiang and Yuzo Ninomiya and Robert F Margolskee},
  journal={Science},
  year={2003},
  volume={301 5634},
  pages={
          850-3
        }
}
The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors. Here,we show that mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and… CONTINUE READING
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