Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.

@article{Schmid2004DetectionOS,
  title={Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.},
  author={Thomas Ernst Schmid and Martin H Brinkworth and F Hill and Eddie D Sloter and Axel Kamischke and Francesco Marchetti and Eberhard Nieschlag and Andrew J. Wyrobek},
  journal={Human reproduction},
  year={2004},
  volume={19 6},
  pages={1395-400}
}
BACKGROUND Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of ICSI, which can enable men with severely impaired sperm production to father children. Several papers have been published reporting aneuploidy in oligozoospermic patients, but relatively little is known about… CONTINUE READING