Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine

@article{Kentar2020DetectionOS,
  title={Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine},
  author={Modar Kentar and Martina Mann and Felix Sahm and Arturo Olivares-Rivera and Ren{\'a}n S{\'a}nchez-Porras and Roland Zerelles and Oliver W. Sakowitz and Andreas Unterberg and Edgar Santos},
  journal={Acta Neurochirurgica},
  year={2020},
  volume={162},
  pages={581-592}
}
Background The main objective of this study was to generate a hemodynamically stable swine model to detect spreading depolarizations (SDs) using electrocorticography (ECoG) and intrinsic optical signal (IOS) imaging and laser speckle flowmetry (LSF) after a 30-h middle cerebral artery (MCA) occlusion (MCAo) in German Landrace Swine. Methods A total of 21 swine were used. The study comprised a training group (group 1, n = 7), a group that underwent bilateral craniectomy and MCAo (group 2, n = 10… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
A new model of focal cerebral ischemia in the miniature pig.
TLDR
This new model of focal cerebral ischemia induces a reproducible amount of ischemic damage in both gray and white matter, and has significant utility for studies of the pathophysiology of ischemie in the gyrencephalic brain and for assessment of the therapeutic efficacy of drugs prior to the initiation of human clinical trials. Expand
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study
TLDR
The feasibility of a large animal model of malignant MCA infarction by performing transcranial occlusion of the MCA in the common pig is documented, as an alternative to lisencephalic animals, and may be useful for detailed studies of cerebral ischemia mechanisms and the development of neuroprotective strategies. Expand
Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain
TLDR
The gyrencephalic brain is capable of irregular SD propagation patterns and may promote the presence of re-entrance waves, such as spirals and reverberating waves. Expand
Simultaneous, live imaging of cortical spreading depression and associated cerebral blood flow changes, by combining voltage-sensitive dye and laser speckle contrast methods
TLDR
A new method is described for the simultaneous, live imaging of local cellular depolarization and CBF changes (i.e. two variables with well-defined and important biological significance), through a closed cranial window prepared in anesthetized rats, to help advance knowledge in epilepsy, CBF pharmacology, and neurovascular coupling under normal and pathophysiological conditions. Expand
Cortical spreading depression dynamics can be studied using intrinsic optical signal imaging in gyrencephalic animal cortex.
TLDR
IOS imaging enables an in vivo evaluation of CSD dynamics over a large surface of gyrencephalic brain using intrinsic optical signal imaging during the induction, propagation, and termination of cortical spreading depolarizations (CSDs). Expand
Experimental Model of Lacunar Infarction in the Gyrencephalic Brain of the Miniature Pig: Neurological Assessment and Histological, Immunohistochemical, and Physiological Evaluation of Dynamic Corticospinal Tract Deformation
TLDR
A new experimental model of lacunar infarction in the miniature pig was developed to investigate the pathophysiological changes in the corticospinal tract from the acute to chronic phases and induces a reproducible infarct in subcortical white matter with a measurable functional deficit and evidence of penumbral tissue acutely. Expand
Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model
TLDR
The development and characterize of a novel pig middle cerebral artery occlusion (MCAO) ischemic stroke model suggest that the pig model is potentially a robust system for the study of stroke pathophysiology and potential diagnostics and therapeutics. Expand
Ketamine modulation of the haemodynamic response to spreading depolarization in the gyrencephalic swine brain
  • R. Sánchez-Porras, E. Santos, +5 authors O. Sakowitz
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
TLDR
The findings indicate that frequent SDs caused a persistent increase in the baseline pial arterial diameter, which can lead to a diminished capacity to further dilate, and the haemodynamic response to SD can be modulated by continuous infusion of ketamine. Expand
Large field-of-view movement-compensated intrinsic optical signal imaging for the characterization of the haemodynamic response to spreading depolarizations in large gyrencephalic brains
  • M. Schöll, E. Santos, +10 authors H. Dickhaus
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
TLDR
Movement-compensated IOS is strongly suggested for the investigation of the role of haemodynamic responses to SDs during the development of secondary brain damage and in particular to examine the effect of potential therapeutic interventions in gyrencephalic brains. Expand
Endovascular external carotid artery occlusion for brain selective targeting: a cerebrovascular swine model
TLDR
An effective, selective vascular brain model in swine is developed that may be useful as a practical and cost-reducing intermediate step for evaluating target dose–responses for central nervous system drugs and brain selective interventions, such as local hypothermia. Expand
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