Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease.

@article{Viappiani2006DetectionOS,
  title={Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease.},
  author={Serena Viappiani and Richard L Schulz},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 6},
  pages={H2167-8}
}
THE OXIDATIVE MODIFICATION of proteins is a natural consequence of aerobic life and is also recognized to play a crucial role in the pathological response of cells to increased oxidative stress. Several oxidative modifications of a protein can occur as a result of oxidative stress. These can range from the facile oxidation of cysteine residues to changes caused by higher levels of oxidative stress, resulting in covalent crosslinking with other proteins (whether by S-S linkage or by 2-2 biphenyl… CONTINUE READING