Detection of specific collagen types in normal and keratoconus corneas.

@article{Newsome1981DetectionOS,
  title={Detection of specific collagen types in normal and keratoconus corneas.},
  author={David A. Newsome and Jean Michel Foidart and John R. Hassell and Jay H. Krachmer and Merlyn M. Rodrigues and Stephen Ira Katz},
  journal={Investigative ophthalmology & visual science},
  year={1981},
  volume={20 6},
  pages={
          738-50
        }
}
Keratoconus is a corneal disease of unknown cause that involves a progressive thinning and scarring of the corneal connective tissue. We examined normal human and keratoconus corneas, including one healed penetrating keratoplasty specimen. Organ cell cultures of normal and keratoconus corneal specimens were labeled with radioactive proline and analyzed by CM-cellulose chromatography and slab gel electrophoresis to determine collagen biosynthesis. Collagen types I and III were synthesized in… CONTINUE READING

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