Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis.

@article{Alonso1997DetectionOS,
  title={Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis.},
  author={Ana Alonso and Pablo Mart{\'i}n and Cristina Albarr{\'a}n and B Aquilera and {\'O}scar Garc{\'i}a and A{\'i}da Guzm{\'a}n and Harold Oliva and Manuel Sancho},
  journal={Electrophoresis},
  year={1997},
  volume={18 5},
  pages={682-5}
}
Each entire hypervariable region of the mitochondrial DNA control region was screened for mutations from paired normal and tumor DNA corresponding to a group of 21 patients (13 colorectal and 8 gastric adenocarcinomas) using both heteroduplex analysis and single-strand conformation analysis. These two mutation scanning strategies allowed the identification… CONTINUE READING