Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.

@article{Luceri2000DetectionOS,
  title={Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.},
  author={Cristina Luceri and Carlotta De Filippo and Giovanna Caderni and L Gambacciani and Maddalena Salvadori and Augusto Giannini and Piero Dolara},
  journal={Carcinogenesis},
  year={2000},
  volume={21 9},
  pages={1753-6}
}
Colon carcinogenesis induced in rats by azoxymethane (AOM) is a useful experimental model as it mimics the human adenoma-carcinoma sequence and allows the study of dietary variation and of the effects of chemopreventive substances. Alterations of specific oncogenes and tumor suppressor genes (APC and K-ras) play roles at different stages of this carcinogenesis process. Recently, it has been suggested that genomic instability is the necessary step for the generation of multiple mutations… CONTINUE READING

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