Detection of soluble class I molecules (non HLA-A or HLA-B) in serum, spleen membranes and lymphocytes in culture.

@article{Villar1989DetectionOS,
  title={Detection of soluble class I molecules (non HLA-A or HLA-B) in serum, spleen membranes and lymphocytes in culture.},
  author={Luisa M Villar and Garbi{\~n}e Roy and I L{\'a}zaro and Jos{\'e} Carlos {\'A}lvarez-Cerme{\~n}o and Marcelo Gonz{\'a}lez and Jos{\'e} Antonio Brieva and M L Del la Sen and G Leoro and Alfredo Bootello and Pedro G{\'o}nzalez-Porqu{\'e}},
  journal={European journal of immunology},
  year={1989},
  volume={19 10},
  pages={1835-9}
}
Soluble major histocompatibility complex class I molecules (sHLA) present in human serum can be resolved by gel filtration into two different peaks with an apparent molecular mass of about 200 kDa (30% of the total) and 50-60 kDa (60%-70%). The serological analysis of the peaks shows that A or B specificities can only be detected in the 200 kDa peak while both are recognized by the monomorphic W6/32 monoclonal antibody (mAb) and anti-beta 2-microglobulin mAb. Such sHLA (non HLA-A or -B… CONTINUE READING

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