Detection of soft-tissue infections and osteomyelitis using a technetium-99m-labeled anti-granulocyte monoclonal antibody fragment.

@article{Becker1994DetectionOS,
  title={Detection of soft-tissue infections and osteomyelitis using a technetium-99m-labeled anti-granulocyte monoclonal antibody fragment.},
  author={Wendy S Becker and Jennifer Berndt Bair and Thomas Behr and Roland Repp and H Streckenbach and Harald Beck and Martin Gramatzki and M J Winship and David M. Goldenberg and Friedrich Wolf},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1994},
  volume={35 9},
  pages={1436-43}
}
UNLABELLED Imaging of osteomyelitis and soft-tissue infections can be problematic with currently available agents; bone scans are often false-positive. Indium-111-oxine and 99mTc-HMPAO white blood cell (WBC) scans require ex vivo handling of blood with potential exposure to infectious agents, and 99mTc-antigranulocyte (IgG1) antibodies need 24 hr for final diagnosis. METHODS We investigated the use of 99mTc-murine anti-granulocyte monoclonal Fab' fragment in 20 patients with suspected… CONTINUE READING

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