Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe.

@article{Zhao2012DetectionOS,
  title={Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe.},
  author={Zheng-yun Zhao and Marie San and Jean-Louis H. A. Duprey and J. R. Arrand and Joseph S. Vyle and James H. Tucker},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 1},
  pages={129-32}
}
Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the synthesised target sequences, probe-target duplex formation could lead to enhanced or attenuated fluorescence emission from the anthracene, enabling detection of a proximal base-pair as either matching or mismatching. 
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS