Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives.

@article{Steele2005DetectionOS,
  title={Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives.},
  author={Andrew J Steele and Ammar Al-Chalabi and Kimberly Patricia Ferrante and Merit Ester Cudkowicz and R. H. Brown and Jeremy A. Garson},
  journal={Neurology},
  year={2005},
  volume={64 3},
  pages={454-8}
}
BACKGROUND Retroviral involvement in the etiology of sporadic ALS has been suspected for several years since the recognition that both murine and human retroviruses can cause motor neuron disease-like syndromes. In a pilot study, an increased prevalence of a retroviral marker (reverse transcriptase [RT] activity) was demonstrated in the serum of British patients with ALS. The current investigation was designed to confirm and extend these findings in a geographically distinct patient cohort… CONTINUE READING
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