Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification.

@article{Greenberg1989DetectionOS,
  title={Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification.},
  author={Steven J. Greenberg and Garth D. Ehrlich and Mark A. Abbott and B J Hurwitz and Thomas A. Waldmann and Bernard J Poiesz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 8},
  pages={2878-82}
}
Twenty-one patients with multiple sclerosis, chronic progressive type, were examined for DNA sequences homologous to a human retrovirus. Genomic DNA from peripheral blood mononuclear cells was analyzed for the presence of homologous sequences to the human T-cell leukemia/lymphoma virus type I (HTLV-I) long terminal repeat, 3' gag, pol, and env domains by the enzymatic in vitro gene amplification technique, polymerase chain reaction. Positive identification of homologous pol sequences was made… CONTINUE READING