Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

Abstract

Nitration of protein tyrosine residues (nY) is a marker of oxidative stress and may alter the biological activity of the modified proteins. The aim of this study was to develop antibodies toward site-specific nY-modified proteins and to use histochemistry and immunoblotting to demonstrate protein nitration in tissues. Affinity-purified polyclonal antibodies… (More)

Topics

9 Figures and Tables

Slides referencing similar topics