Detection of replication competent retrovirus and lentivirus.

  title={Detection of replication competent retrovirus and lentivirus.},
  author={Lakshmi Sastry and Kenneth G Cornetta},
  journal={Methods in molecular biology},
Retroviral vectors based on murine leukemia viruses (MuLV) have been used in clinical investigations for over a decade. Alternative retroviruses, most notably vectors based on HIV-1 and other lentiviruses, are now entering into clinical trials. Although vectors are designed to be replication defective, recombination events during vector production could lead to the generation of replication competent retroviruses (RCR) or replication competent lentiviruses (RCL). Careful screening of vector… CONTINUE READING
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