Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

@article{Bellido1996DetectionOR,
  title={Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.},
  author={Teresita M. Bellido and Neil I Stahl and Thomas Farruggella and Vict{\'o}ria Zeghbi Cochenski Borba and George D. Yancopoulos and Stavros C Manolagas},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 2},
  pages={431-7}
}
The functional receptor complexes assembled in response to interleukin-6 and -11 (IL-6 and IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), all involve the signal transducer gp130: IL-6 and IL-11 induce homodimerization of gp130, while the rest heterodimerize gp130 with other gp130-related beta subunits. Some of these cytokines (IL-6, IL-11, and CNTF) also require a specificity-determining alpha subunit not directly involved in signaling. We… CONTINUE READING