Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

@article{Karttunen1992DetectionOR,
  title={Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.},
  author={J. Karttunen and Susan Walsh Sanderson and Nilabh Shastri},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 13},
  pages={
          6020-4
        }
}
The alpha/beta T-cell receptor a complex ligand formed by the association of antigenic peptides with molecules of the major histocompatibility complex (MHC). The inherent limitations of the conventional T-cell activation assays used to detect these peptide/MHC ligands have, until now, hampered the development of expression cloning systems for T-cell antigens. To overcome these limitations, we have recently introduced a method for detecting ligand-induced activation of individual T cells. This… CONTINUE READING

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