Detection of protein unfolding and fluctuations by native state hydrogen exchange

@inproceedings{Chamberlain1997DetectionOP,
  title={Detection of protein unfolding and fluctuations by native state hydrogen exchange},
  author={Aaron Keith Chamberlain and Tracy M. Handel and Susan Marqusee},
  year={1997}
}
Publisher Summary Hydrogen exchange can monitor protein fluctuations and opening events in many protons throughout the molecule simultaneously. Protein amide hydrogen exchange is an extremely powerful technique for studies on protein folding, stability, and structure. It allows probing different regions of a protein simultaneously and has a high degree of sensitivity. Because of this, amide hydrogen exchange presents a unique merging of energetic and structural information. Recently, several… CONTINUE READING

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