Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3.

@article{Tan2007DetectionOP,
  title={Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3.},
  author={S C Tan and Hiroshi Ida and Quek-Choon Lau and Boon-cher Goh and W S Chieng and Marie Loh and Yoshiaki Ito},
  journal={Oncology reports},
  year={2007},
  volume={18 5},
  pages={1225-30}
}
The purpose was to validate the use of RUNX3 as a potential biomarker for detection of cancer in serum samples and to determine its sensitivity alone and in combination with p16, RASSF1A and CDH1 using methylation-specific polymerase chain reaction (MSP). We examined the promoter methylation status of RUNX3, p16, RASSF1A and CDH1 by MSP using the serum of 70 metastatic breast, non-small cell lung, gastric, pancreatic, colorectal or hepatocellular carcinomas. The DNA from 10 healthy serum… CONTINUE READING
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