Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay.

@article{Edgeworth2011DetectionOP,
  title={Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay.},
  author={Julie Ann Edgeworth and Michael. Farmer and Anita Sicilia and Paul Tavares and Jonathan Beck and Tracy A. Campbell and Jessica Lowe and Simon Mead and Peter Rudge and John Collinge and Graham S. Jackson},
  journal={Lancet},
  year={2011},
  volume={377 9764},
  pages={487-93}
}
BACKGROUND Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder originating from exposure to bovine-spongiform-encephalopathy-like prions. Prion infections are associated with long and clinically silent incubations. The number of asymptomatic individuals with vCJD prion infection is unknown, posing risk to others via blood transfusion, blood products, organ or tissue grafts, and contaminated medical instruments. We aimed to establish the sensitivity and specificity of… CONTINUE READING
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