Detection of preclinical motor neurone loss in SOD1 mutation carriers using motor unit number estimation.

@article{Aggarwal2002DetectionOP,
  title={Detection of preclinical motor neurone loss in SOD1 mutation carriers using motor unit number estimation.},
  author={Arun Aggarwal and Garth A. Nicholson},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2002},
  volume={73 2},
  pages={199-201}
}
OBJECTIVE To determine the pattern of motor neurone loss in amyotrophic lateral sclerosis (ALS). In particular, to determine whether there is a gradual life long presymptomatic motor neurone loss or, alternatively, a sudden catastrophic loss just before the onset of symptoms. METHOD The statistical motor unit number estimation (MUNE) technique was used in a longitudinal study of 19 asymptomatic carriers of the Cu, Zn superoxide dismutase 1 (SOD1) gene. MUNE results were compared with those of… CONTINUE READING

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