Detection of potential GDF6 regulatory elements by multispecies sequence comparisons and identification of a skeletal joint enhancer.

@article{Portnoy2005DetectionOP,
  title={Detection of potential GDF6 regulatory elements by multispecies sequence comparisons and identification of a skeletal joint enhancer.},
  author={Matthew E. Portnoy and Kelly J McDermott and Anthony Antonellis and Elliott H. Margulies and Arjun B. Prasad and David M. Kingsley and Eric D. Green and Douglas P. Mortlock},
  journal={Genomics},
  year={2005},
  volume={86 3},
  pages={295-305}
}
The identification of noncoding functional elements within vertebrate genomes, such as those that regulate gene expression, is a major challenge. Comparisons of orthologous sequences from multiple species are effective at detecting highly conserved regions and can reveal potential regulatory sequences. The GDF6 gene controls developmental patterning of skeletal joints and is associated with numerous, distant cis-acting regulatory elements. Using sequence data from 14 vertebrate species, we… CONTINUE READING