Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomas.

@article{Kim2015DetectionOP,
  title={Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomas.},
  author={Bo Hyun Kim and In Joo Kim and Byung Joo Lee and Jin Choon Lee and In Suk Kim and Seong Jang Kim and Won Jin Kim and Yun Kyung Jeon and Sang Soo Kim and Yong Ki Kim},
  journal={Yonsei medical journal},
  year={2015},
  volume={56 3},
  pages={634-40}
}
PURPOSE The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of free circulating mutant BRAF(V600E) in predicting the advanced disease of PTC. MATERIALS AND METHODS Seventy seven matched tumor and plasma samples obtained from patients with both benign and PTC were analyzed for BRAF(V600E) mutation using a peptide nucleic acid (PNA) clamp real-time… CONTINUE READING