Detection of parent-of-origin effects for quantitative traits in complete and incomplete nuclear families with multiple children.

@article{He2011DetectionOP,
  title={Detection of parent-of-origin effects for quantitative traits in complete and incomplete nuclear families with multiple children.},
  author={Feng He and Ji-Yuan Zhou and Yue-Qing Hu and Fengzhu Sun and Jingyuan Yang and Shili Lin and Wing Kam Fung},
  journal={American journal of epidemiology},
  year={2011},
  volume={174 2},
  pages={226-33}
}
For a diallelic genetic marker locus, tests like the parental-asymmetry test (PAT) are simple and powerful for detecting parent-of-origin effects. However, these approaches are applicable only to qualitative traits and thus are currently not suitable for quantitative traits. In this paper, the authors propose a novel class of PAT-type parent-of-origin effects tests for quantitative traits in families with both parents and an arbitrary number of children, which is denoted by Q-PAT(c) for some… CONTINUE READING