Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue.

  title={Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue.},
  author={Bruno Stuhlm{\"u}ller and Elke Kunisch and Juliane K Franz and Lorena Mart{\'i}nez-Gamboa and Maria del Mar Garcı́a Hern{\'a}ndez and Axel Pruss and N. Ulbrich and Volker A. Erdmann and Gerd ‐ R{\"u}diger Burmester and Raimund W. Kinne},
  journal={The American journal of pathology},
  volume={163 3},
The expression of oncofetal H19 RNA and its localization/cellular source was analyzed in synovial tissue (ST) and isolated synovial macrophages (Mphi) or synovial fibroblasts (SFBs) by reverse transcriptase-polymerase chain reaction (RT-PCR), in situ hybridization, and immunohistochemistry. RT-PCR showed significantly higher H19 expression in ST from patients with rheumatoid arthritis (RA) (P = 0.000) and osteoarthritis (OA) (P = 0.009) than in normal/joint trauma controls (N/JT), but… CONTINUE READING


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